RUNX3 is multifunctional in carcinogenesis of multiple solid tumors

Abstract

The study of RUNX3 in tumor pathogenesis is a rapidly expanding area of cancer research. Functional inactivation of RUNX3—through mutation, epigenetic silencing, or cytoplasmic mislocalization—is frequently observed in solid tumors of diverse origins. This alone indicates that RUNX3 inactivation is a major risk factor in tumorigenesis and that it occurs… (More)
DOI: 10.1038/onc.2010.88

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