RUNX3 is down‐regulated in glioma by Myc‐regulated miR‐4295

  title={RUNX3 is down‐regulated in glioma by Myc‐regulated miR‐4295},
  author={X. Li and J. Zheng and Hongyu Diao and Y. Liu},
  journal={Journal of Cellular and Molecular Medicine},
  pages={518 - 525}
  • X. Li, J. Zheng, +1 author Y. Liu
  • Published 2016
  • Biology, Medicine
  • Journal of Cellular and Molecular Medicine
  • MicroRNAs are increasingly reported as tumour suppressors that regulate gene expression after transcription. Our results demonstrated that miR‐4295 is overexpression in glioma tissues and its level is significantly correlated with clinical stage. We also found that miR‐4295 inhibited the cell G0/G1 arrest and apoptosis leading to promoted cell proliferation and activity. The murine modelling study revealed that female nude mice injected with U87/anti‐miR‐4295 exhibit subcutaneous tumours in the… CONTINUE READING
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