RUNX3 is down‐regulated in glioma by Myc‐regulated miR‐4295

@article{Li2016RUNX3ID,
  title={RUNX3 is down‐regulated in glioma by Myc‐regulated miR‐4295},
  author={X. Li and J. Zheng and Hongyu Diao and Y. Liu},
  journal={Journal of Cellular and Molecular Medicine},
  year={2016},
  volume={20},
  pages={518 - 525}
}
  • X. Li, J. Zheng, +1 author Y. Liu
  • Published 2016
  • Biology, Medicine
  • Journal of Cellular and Molecular Medicine
    • MicroRNAs are increasingly reported as tumour suppressors that regulate gene expression after transcription. Our results demonstrated that miR‐4295 is overexpression in glioma tissues and its level is significantly correlated with clinical stage. We also found that miR‐4295 inhibited the cell G0/G1 arrest and apoptosis leading to promoted cell proliferation and activity. The murine modelling study revealed that female nude mice injected with U87/anti‐miR‐4295 exhibit subcutaneous tumours in the… CONTINUE READING
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    References

    SHOWING 1-10 OF 42 REFERENCES
    Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status
    • 306
    • PDF
    The Neuronal MicroRNA miR-326 Acts in a Feedback Loop with Notch and Has Therapeutic Potential against Brain Tumors
    • 198
    • PDF
    MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators
    • 834
    • PDF
    MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells.
    • 645
    • PDF
    miR-21 and 221 upregulation and miR-181b downregulation in human grade II–IV astrocytic tumors
    • 206
    Comprehensive analysis of the functional microRNA–mRNA regulatory network identifies miRNA signatures associated with glioma malignant progression
    • 95
    • PDF
    RUNX3 expression is lost in glioma and its restoration causes drastic suppression of tumor invasion and migration
    • 41
    Lineage-specific RUNX3 hypomethylation marks the preneoplastic immune component of gastric cancer
    • 15
    • PDF
    Overexpression of deubiquitinating enzyme USP28 promoted non-small cell lung cancer growth
    • 35
    Downregulation of RUNX3 and TES by hypermethylation in glioblastoma
    • 126
    • PDF