RUNX3 Inactivation in Colorectal Polyps Arising Through Different Pathways of Colonic Carcinogenesis

@article{Subramaniam2009RUNX3II,
  title={RUNX3 Inactivation in Colorectal Polyps Arising Through Different Pathways of Colonic Carcinogenesis},
  author={Manish Mani Subramaniam and Jason Yongsheng Chan and Richie Soong and Kosei Ito and Khay Guan Yeoh and Reuben Kong Min Wong and Thomas Guenther and Olivia C C Will and Chee L Chen and Marian Priyanthi Kumarasinghe and Yoshiaki Ito and Manuel Salto-Tellez},
  journal={The American Journal of Gastroenterology},
  year={2009},
  volume={104},
  pages={426-436}
}
OBJECTIVES:We hypothesized that RUNX3 inactivation by promoter hypermethylation in colorectal polyps is an early molecular event in colorectal carcinogenesis.METHODS:RUNX3 protein expression was analyzed immunohistochemically in 50 sporadic colorectal polyps comprising 19 hyperplastic polyps (HPs), 14 traditional serrated adenomas (TSAs), and 17 sporadic traditional adenomas (sTAs) as well as in 19 familial adenomatous polyposis (FAP) samples from 10 patients showing aberrant crypt foci (ACF… CONTINUE READING
17 Citations
54 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 54 references

RUNX 3 cooperates with FoxO 3 a to induce apoptosis in gastric cancer cells

  • Y Yamamura, WL Lee, K Inoue
  • J Biol Chem
  • 2006

Similar Papers

Loading similar papers…