RU486-induced growth inhibition of human endometrial cells.

  title={RU486-induced growth inhibition of human endometrial cells.},
  author={Ana Alvarez Murphy and Ming-zhu Zhou and S Malkapuram and Nalini Santanam and Sampath Parthasarathy and Neil Sidell},
  journal={Fertility and sterility},
  volume={74 5},
OBJECTIVE To determine the direct action of RU486 on endometrial cell proliferation and to differentiate whether the antioxidant or the antiprogesterone property of RU486 is predominately responsible for its effect on cell growth. DESIGN In vitro study comparing the effects of RU486 (antiprogesterone and antioxidant), reduced RU486 (antioxidant), ZK112,993 (antiprogesterone), and lazaroid U74,500A (antioxidant) on endometrial cell growth. The human endometrial cell line EM42 was used in… CONTINUE READING


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