RU 24969, a 5-HT1A/1B agonist, elevates brain stimulation reward thresholds: an effect reversed by GR 127935, a 5-HT1B/1D antagonist

  title={RU 24969, a 5-HT1A/1B agonist, elevates brain stimulation reward thresholds: an effect reversed by GR 127935, a 5-HT1B/1D antagonist},
  author={Amanda A. Harrison and Loren H. Parsons and George F. Koob and Athina Markou},
Abstract Recent studies suggest that serotonergic neurotransmission through the serotonin-1B (5-HT1B) receptor is involved in reward processes. The purpose of the present studies was to investigate the effects of 5-HT1B receptor activation and antagonism on intracranial self-stimulation (ICSS) reward using a current-threshold ICSS task. Male Wistar rats were prepared with bipolar electrodes in the lateral hypothalamus. When stable baseline thresholds were established, the effects of the mixed 5… 

Effects of systemic 5-HT(1B) receptor compounds on ventral tegmental area intracranial self-stimulation thresholds in rats.

Effects of systemic and intra-nucleus accumbens 5-HT2C receptor compounds on ventral tegmental area self-stimulation thresholds in rats

The results suggest that 5-HT2C receptors play an inhibitory role in regulating reward-related behaviour while 5- HT2C receptor activation in the NAc shell did not appear to influence VTA ICSS behaviour under the present experimental conditions.

Serotonergic manipulations both potentiate and reduce brain stimulation reward in rats: involvement of serotonin-1A receptors.

  • A. HarrisonA. Markou
  • Biology, Psychology
    The Journal of pharmacology and experimental therapeutics
  • 2001
The hypothesis that serotonin exerts an inhibitory influence on reward processes is supported, suggested here that the reward-potentiating effects of systemically administered low doses of 8-OH-DPAT may be the result of reduced serotonergic neurotransmission.

Blockade of serotonin 5-HT1B and 5-HT2A receptors suppresses the induction of locomotor activity by 5-HT reuptake inhibitors, citalopram and fluvoxamine, in NMRI mice exposed to a novel environment: a comparison to other 5-HT receptor subtypes

The locomotor response to SSRIs of mice exposed to a novel environment is mediated via 5-HT1B and5-HT2A receptors, and the significance of these observations to the clinical actions ofSSRIs will be of interest to elucidate.

Effect of serotonin (5-HT)1B receptor ligands on cocaine sensitization in rats.

The results indicate that 5-HT1B receptors are involved in neither the development nor the expression of sensitization to cocaine-induced locomotor hyperactivity, and that repeated administration of cocaine leads to an increased functional reactivity of these receptors.

Effects of serotonin (5-HT)(1B) receptor ligands on cocaine-seeking behavior in rats.

It is indicated that tonic activation of 5-HT(1B) receptors is involved in cocaine- and cue-induced reinstatement of cocaine-seeking behavior and that the inhibitory effects of 4-HT (4-HT) receptor antagonists on these phenomena are directly related to motivational aspects of cocaine abuse.



Serotonin1B receptor stimulation enhances dopamine-mediated reinforcement

Pretreatment with the 5-HT1A/1B receptor agonist CGS-12066B dose-dependently reduced the self-administration of GBR-12909 by increasing the interval between drug injections, consistent with a enhancement of the reinforcing effects of GBS, suggesting that the simultaneous stimulation of multiple5-HT receptor subtypes by the indirect 5-ht agonist properties of cocaine may mask the effect of 5- HT1B receptors on DA-mediated reinforcement.

Modulation of the discriminative stimulus properties of cocaine by 5-HT1B and 5-HT2C receptors.

Several 5-HT receptor compounds do not substitute for cocaine, but not antagonists, differentially modulate the stimulus effects of cocaine.

Serotonin-facilitated dopamine release in vivo: pharmacological characterization.

The receptor specificity of serotonin (5-HT) agonist-induced facilitation of dopamine (DA) release was assessed by using in vivo microdialysis and coperfusion of antagonists with agonists indicated involvement of 5-HT1 and 5- HT3 receptors and a lack of involvement of 6-methyl-5H-thiazolo-1-pyrimidin-5-one receptors.