RU 24969, a 5-HT1A/1B agonist, elevates brain stimulation reward thresholds: an effect reversed by GR 127935, a 5-HT1B/1D antagonist

@article{Harrison1999RU2A,
  title={RU 24969, a 5-HT1A/1B agonist, elevates brain stimulation reward thresholds: an effect reversed by GR 127935, a 5-HT1B/1D antagonist},
  author={Amanda A. Harrison and Loren H. Parsons and George F. Koob and Athina Markou},
  journal={Psychopharmacology},
  year={1999},
  volume={141},
  pages={242-250}
}
Abstract Recent studies suggest that serotonergic neurotransmission through the serotonin-1B (5-HT1B) receptor is involved in reward processes. The purpose of the present studies was to investigate the effects of 5-HT1B receptor activation and antagonism on intracranial self-stimulation (ICSS) reward using a current-threshold ICSS task. Male Wistar rats were prepared with bipolar electrodes in the lateral hypothalamus. When stable baseline thresholds were established, the effects of the mixed 5… 

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Effect of serotonin (5-HT)1B receptor ligands on cocaine sensitization in rats.

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Effects of serotonin (5-HT)(1B) receptor ligands on cocaine-seeking behavior in rats.

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...

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