RTOG 0529: a phase 2 evaluation of dose-painted intensity modulated radiation therapy in combination with 5-fluorouracil and mitomycin-C for the reduction of acute morbidity in carcinoma of the anal canal.

@article{Kachnic2013RTOG0A,
  title={RTOG 0529: a phase 2 evaluation of dose-painted intensity modulated radiation therapy in combination with 5-fluorouracil and mitomycin-C for the reduction of acute morbidity in carcinoma of the anal canal.},
  author={Lisa Ann Kachnic and Kathryn Winter and Robert J. Myerson and Michael D. E. Goodyear and John D Willins and Jacqueline Esthappan and Michael G. Haddock and Marvin H Rotman and Parag J. Parikh and Howard P. Safran and Christopher G Willett},
  journal={International journal of radiation oncology, biology, physics},
  year={2013},
  volume={86 1},
  pages={27-33}
}
PURPOSE A multi-institutional phase 2 trial assessed the utility of dose-painted intensity modulated radiation therapy (DP-IMRT) in reducing grade 2+ combined acute gastrointestinal and genitourinary adverse events (AEs) of 5-fluorouracil (5FU) and mitomycin-C (MMC) chemoradiation for anal cancer by at least 15% compared with the conventional radiation/5FU/MMC arm from RTOG 9811. METHODS AND MATERIALS T2-4N0-3M0 anal cancer patients received 5FU and MMC on days 1 and 29 of DP-IMRT, prescribed… CONTINUE READING
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Dosimetric comparison of dosepainted intensity modulated radiation therapy vs. conventional radiation therapy for anal cancer

  • HK Tsai, TS Hong, J Willins
  • JClinOncol
  • 2006
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