RTEF-1, a novel transcriptional stimulator of vascular endothelial growth factor in hypoxic endothelial cells.

@article{Shie2004RTEF1AN,
  title={RTEF-1, a novel transcriptional stimulator of vascular endothelial growth factor in hypoxic endothelial cells.},
  author={Jue-Lon Shie and Guifu Wu and Jiaping Wu and Fen-Fen Liu and Roger J. Laham and P. Oettgen and Jian Li},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 24},
  pages={
          25010-6
        }
}
Vascular endothelial growth factor (VEGF) is an angiogenic growth factor known to be up-regulated in ischemic heart and hypoxic endothelial cells. However, the transcriptional regulation of VEGF in hypoxia-induced angiogenesis is not fully understood. Transcriptional enhancer factor-1 (TEF-1) is a transcriptional factor family that can regulate many genes expressed in cardiac and skeletal muscle cells by binding to myocyte-specific chloramphenicol acetyltransferase heptamer elements in the… CONTINUE READING

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