RT-PCR permits simultaneous genotyping of thiopurine S-methyltransferase allelic variants by multiplex induced heteroduplex analysis.

Abstract

Thiopurine-based drugs are a widely prescribed group of medications. Their tolerance and effectiveness is dependent on an individual's ability to metabolize these compounds. An essential enzyme for the metabolism of these drugs is thiopurine S-methyltransferase (TPMT), whose activity is subject to genetic variation. Genotyping of the most frequent allelic… (More)

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@article{Wood2004RTPCRPS, title={RT-PCR permits simultaneous genotyping of thiopurine S-methyltransferase allelic variants by multiplex induced heteroduplex analysis.}, author={N. A. P. Wood and Adrian Fraser and Jeffrey L Bidwell and Graham R Standen}, journal={Human mutation}, year={2004}, volume={24 1}, pages={93-9} }