RT-PCR for tyrosinase-mRNA-positive cells in peripheral blood: evaluation strategy and correlation with known prognostic markers in 123 melanoma patients.

@article{Farthmann1998RTPCRFT,
  title={RT-PCR for tyrosinase-mRNA-positive cells in peripheral blood: evaluation strategy and correlation with known prognostic markers in 123 melanoma patients.},
  author={Birgit Farthmann and J{\"u}rgen Eberle and Konstantin Krasagakis and Michaela Gstoettner and Na Wang and Susanne Bisson and Constantin E. Orfanos},
  journal={The Journal of investigative dermatology},
  year={1998},
  volume={110 3},
  pages={
          263-7
        }
}
Reverse transcriptase polymerase chain reaction for the detection of tyrosinase-mRNA-positive cells in peripheral blood of melanoma patients, as a possible marker of hematogenous dissemination, has demonstrated varying detection rates. This study examined the sensitivity and reproducibility of the technique using a protocol of multiple polymerase chain reaction to determine circulating melanocytic cells. For each of the 123 melanoma patients included in this study, four nested polymerase chain… CONTINUE READING
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