RT-PCR diagnosis of recurrent rearrangements in pediatric acute lymphoblastic leukemia in Argentina.

@article{Alonso2012RTPCRDO,
  title={RT-PCR diagnosis of recurrent rearrangements in pediatric acute lymphoblastic leukemia in Argentina.},
  author={Cristina Noem{\'i} Alonso and Marta S. Gallego and Jorge Gabriel Rossi and Adriana Medina and Patricia L Rubio and Andrea Raquel Bernasconi and Pedro A. Zubizarreta and Maria Sara Felice},
  journal={Leukemia research},
  year={2012},
  volume={36 6},
  pages={704-8}
}
The present study was performed to establish the prevalence of the recurrent fusion transcripts in Argentinean pediatric patients with acute lymphoblastic leukemia (ALL). A total of 380 newly diagnosed children (including 50 infants and 44 T-ALL) were screened by RT-PCR; the incidence of recurrent rearrangements was: ETV6-RUNX1, 12.9%; TCF3-PBX1, 5.0%; BCR-ABL1, 1.6%; and MLL rearrangements, 10.5%. STIL-TAL1 was detected in 22.7% of T-ALL cases. In B-ALL cases, the pEFS was significantly… CONTINUE READING

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