RSV capsid polymorphism correlates with polymerization efficiency and envelope glycoprotein content: implications that nucleation controls morphogenesis.

@article{Butan2008RSVCP,
  title={RSV capsid polymorphism correlates with polymerization efficiency and envelope glycoprotein content: implications that nucleation controls morphogenesis.},
  author={Carmen Butan and Dennis C. Winkler and J Bernard Heymann and Rebecca C. Craven and Alasdair C. Steven},
  journal={Journal of molecular biology},
  year={2008},
  volume={376 4},
  pages={1168-81}
}
We used cryo-electron tomography to visualize Rous sarcoma virus, the prototypic alpharetrovirus. Its polyprotein Gag assembles into spherical procapsids, concomitant with budding. In maturation, Gag is dissected into its matrix, capsid protein (CA), and nucleocapsid moieties. CA reassembles into cores housing the viral RNA and replication enzymes. Evidence suggests that a correctly formed core is essential for infectivity. The virions in our data set range from approximately 105 to… CONTINUE READING
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