RSSsite: a reference database and prediction tool for the identification of cryptic Recombination Signal Sequences in human and murine genomes

@inproceedings{Merelli2010RSSsiteAR,
  title={RSSsite: a reference database and prediction tool for the identification of cryptic Recombination Signal Sequences in human and murine genomes},
  author={Ivan Merelli and Alessandro Guffanti and Marco Fabbri and Andrea Cocito and Laura Furia and Ursula Grazini and Raoul J. P. Bonnal and Luciano Milanesi and Fraser McBlane},
  booktitle={Nucleic Acids Research},
  year={2010}
}
Recombination signal sequences (RSSs) flanking V, D and J gene segments are recognized and cut by the VDJ recombinase during development of B and T lymphocytes. All RSSs are composed of seven conserved nucleotides, followed by a spacer (containing either 12 +/- 1 or 23 +/- 1 poorly conserved nucleotides) and a conserved nonamer. Errors in V(D)J recombination, including cleavage of cryptic RSS outside the immunoglobulin and T cell receptor loci, are associated with oncogenic translocations… CONTINUE READING