RSR1, a ras-like gene homologous to Krev-1 (smg21A/rap1A): role in the development of cell polarity and interactions with the Ras pathway in Saccharomyces cerevisiae.

@article{Ruggieri1992RSR1AR,
  title={RSR1, a ras-like gene homologous to Krev-1 (smg21A/rap1A): role in the development of cell polarity and interactions with the Ras pathway in Saccharomyces cerevisiae.},
  author={Rosamaria Ruggieri and Anna Bender and Yasushi Matsui and Scott Powers and Yoshimi Takai and John R. Pringle and Kunihiro Matsumoto},
  journal={Molecular and cellular biology},
  year={1992},
  volume={12 2},
  pages={758-66}
}
The Saccharomyces cerevisiae ras-like gene RSR1 is particularly closely related to the mammalian gene Krev-1 (also known as smg21A and rap1A). RSR1 was originally isolated as a multicopy suppressor of a cdc24 mutation, which causes an inability to bud or establish cell polarity. Deletion of RSR1 itself does not affect growth but causes a randomization of bud position. We have now constructed mutant alleles of RSR1 encoding proteins with substitutions of Val for Gly at position 12 (analogous to… CONTINUE READING

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