RSK2 drives cell motility by serine phosphorylation of LARG and activation of Rho GTPases

@inproceedings{Shi2018RSK2DC,
  title={RSK2 drives cell motility by serine phosphorylation of LARG and activation of Rho GTPases},
  author={Geng-Xian Shi and Won Seok Yang and Ling Jin and Michelle L Matter and Joe W Ramos},
  booktitle={Proceedings of the National Academy of Sciences of the United States of America},
  year={2018}
}
Directed migration is essential for cell motility in many processes, including development and cancer cell invasion. RSKs (p90 ribosomal S6 kinases) have emerged as central regulators of cell migration; however, the mechanisms mediating RSK-dependent motility remain incompletely understood. We have identified a unique signaling mechanism by which RSK2… CONTINUE READING