RSK promotes prostate cancer progression in bone through ING3, CKAP2, and PTK6-mediated cell survival.

@article{Yu2015RSKPP,
  title={RSK promotes prostate cancer progression in bone through ING3, CKAP2, and PTK6-mediated cell survival.},
  author={Guoyu Yu and Yu-Chen Lee and Chien-Jui Cheng and Chuan-Fen Wu and Jian H. Song and Gary E. Gallick and Li-yuan Yu-lee and Jian Kuang and Sue-Hwa Lin},
  journal={Molecular cancer research : MCR},
  year={2015},
  volume={13 2},
  pages={
          348-57
        }
}
UNLABELLED Prostate cancer has a proclivity to metastasize to bone. The mechanism by which prostate cancer cells are able to survive and progress in the bone microenvironment is not clear. Identification of molecules that play critical roles in the progression of prostate cancer in bone will provide essential targets for therapy. Ribosomal S6 protein kinases (RSK) have been shown to mediate many cellular functions critical for cancer progression. Whether RSK plays a role in the progression of… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 39 REFERENCES

p90 RSK2mediates antianoikis signals by both transcription-dependent and -independent mechanisms

L Jin, LiD, +3 authors J Fan
  • Mol Cell Biol
  • 2013
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Integrin alphavbeta6 promotes an osteolytic program in cancer cells by upregulating MMP2

Anindita Dutta, Jing Li, +13 authors Lucia R. Languino
  • 2014
VIEW 1 EXCERPT