RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells.

@article{Doehn2009RSKIA,
  title={RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells.},
  author={Ulrik Doehn and Camilla Hauge and Scott R. Frank and Claus J Jensen and Katarzyna Duda and Jakob V. Nielsen and Michael S Cohen and Jens Vilstrup Johansen and Benny R. Winther and Leif R\oge Lund and Ole Winther and Jack Taunton and Steen H Hansen and Morten Fr{\"o}din},
  journal={Molecular cell},
  year={2009},
  volume={35 4},
  pages={511-22}
}
The RAS-stimulated RAF-MEK-ERK pathway confers epithelial cells with critical motile and invasive capacities during development, tissue regeneration, and carcinoma progression, often via promoting the epithelial-mesenchymal transition (EMT). Many mechanisms by which ERK exerts this control remain elusive. We demonstrate that the ERK-activated kinase RSK is necessary to induce mesenchymal motility and invasive capacities in nontransformed epithelial and carcinoma cells. RSK is sufficient to… CONTINUE READING
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