RSC Functions as an Early Double-Strand-Break Sensor in the Cell's Response to DNA Damage

@article{Liang2007RSCFA,
  title={RSC Functions as an Early Double-Strand-Break Sensor in the Cell's Response to DNA Damage},
  author={Bing Liang and Jiajing Qiu and Kajan Ratnakumar and Brehon C. Laurent},
  journal={Current Biology},
  year={2007},
  volume={17},
  pages={1432-1437}
}
The detection of a DNA double-strand break (DSB) is necessary to initiate DSB repair. Several proteins, including the MRX/N complex, Tel1/ATM (ataxia telangiectasia mutated), and Mec1/ATR (ATM and Rad3 related), have been proposed as sensors of DNA damage, yet how they recognize the breaks is poorly understood. DSBs occur in the context of chromatin, implicating factors capable of altering local and/or global chromatin structure in the cellular response to DNA damage, including DSB sensing… CONTINUE READING

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tinct roles for the RSC and Swi / Snf ATP - dependent chromatin remodelers in DNA double - strand break repair

  • B. Chai, J. Huang, B. R. Cairns, B. C. Laurent
  • Genes Dev .
  • 2005
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