RS-22A, B and C: new macrolide antibiotics from Streptomyces violaceusniger. I. Taxonomy, fermentation, isolation and biological activities.

@article{Ubukata1995RS22ABA,
  title={RS-22A, B and C: new macrolide antibiotics from Streptomyces violaceusniger. I. Taxonomy, fermentation, isolation and biological activities.},
  author={Makoto Ubukata and Naomasa Shiraishi and Kimie Kobinata and Toshiaki Kudo and Isamu Yamaguchi and Hiroyuki Osada and Y. C. Shen and K. Isono},
  journal={The Journal of antibiotics},
  year={1995},
  volume={48 4},
  pages={289-92}
}
Three novel 36-membered macrolide antibiotics, RS-22A, B and C produced by Streptomyces violaceusniger have been isolated. These antibiotics were purified from an acetone extract of the mycelia followed by butanol extraction, centrifugal partition chromatography and HPLC. RS-22A, B, C showed antimicrobial activity against fungi and Gram-positive bacteria.