RS-102221: A Novel High Affinity and Selective, 5-HT2C Receptor Antagonist

@article{Bonhaus1997RS102221AN,
  title={RS-102221: A Novel High Affinity and Selective, 5-HT2C Receptor Antagonist},
  author={D. W. Bonhaus and Klaus Kurt Weinhardt and M. Taylor and Andre Desouza and P. M. McNeeley and Krystine Szczepanski and David J. Fontana and J. Trinh and Cynthia Rocha and M. W. Dawson and Lee A. Flippin and R. M. Eglen},
  journal={Neuropharmacology},
  year={1997},
  volume={36},
  pages={621-629}
}
The 5-HT2C receptor is one of three closely related receptor subtypes in the 5-HT2 receptor family. 5-HT2A and 5-HT2B selective antagonists have been described. However, no 5-HT2C selective antagonists have yet been disclosed. As part of an effort to further explore the function of 5-HT2C receptors, we have developed a selective 5-HT2C receptor antagonist, RS-102221 (a benzenesulfonamide of 8-[5-(5-amino-2,4-dimethoxyphenyl) 5-oxopentyl]-1,3,8-triazaspiro[4.5]decane-2,4-dione). This compound… Expand
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