RRM2B-Mediated Regulation of Mitochondrial Activity and Inflammation under Oxidative Stress

Abstract

RRM2B is a critical ribonucleotide reductase (RR) subunit that exists as p53-inducible and p53-dependent molecule. The p53-independent regulation of RRM2B has been recently studied, and FOXO3 was identified as a novel regulator of RRM2B. However, the p53-independent regulation of RRM2B, particularly under oxidative stress, remains largely unknown. In this… (More)
DOI: 10.1155/2015/287345

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