RPEL motifs link the serum response factor cofactor MAL but not myocardin to Rho signaling via actin binding.

@article{Guettler2008RPELML,
  title={RPEL motifs link the serum response factor cofactor MAL but not myocardin to Rho signaling via actin binding.},
  author={Sebastian Guettler and Maria K Vartiainen and Francesc Miralles and Banafsh{\'e} Larijani and Richard Treisman},
  journal={Molecular and cellular biology},
  year={2008},
  volume={28 2},
  pages={732-42}
}
Myocardin (MC) family proteins are transcriptional coactivators for serum response factor (SRF). Each family member possesses a conserved N-terminal region containing three RPEL motifs (the "RPEL domain"). MAL/MKL1/myocardin-related transcription factor A is cytoplasmic, accumulating in the nucleus upon activation of Rho GTPase signaling, which alters interactions between G-actin and the RPEL domain. We demonstrate that MC, which is nuclear, does not shuttle through the cytoplasm and that the… CONTINUE READING
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