RPE65 and the Accumulation of Retinyl Esters in Mouse Retinal Pigment Epithelium.

Abstract

The RPE65 protein of the retinal pigment epithelium (RPE) enables the conversion of retinyl esters to the visual pigment chromophore 11-cis retinal. Fresh 11-cis retinal is generated from retinyl esters following photoisomerization of the visual pigment chromophore to all-trans during light detection. Large amounts of esters accumulate in Rpe65-/- mice… (More)
DOI: 10.1111/php.12738

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Cite this paper

@article{Sheridan2017RPE65AT, title={RPE65 and the Accumulation of Retinyl Esters in Mouse Retinal Pigment Epithelium.}, author={Colleen Sheridan and Nicholas Patrick Boyer and Rosalie K. Crouch and Yiannis Koutalos}, journal={Photochemistry and photobiology}, year={2017}, volume={93 3}, pages={844-848} }