RPE-derived factors modulate photoreceptor differentiation: A possible role in the retinal stem cell niche

@article{Sheedlo2007RPEderivedFM,
  title={RPE-derived factors modulate photoreceptor differentiation: A possible role in the retinal stem cell niche},
  author={Harold J. Sheedlo and Thomas J. Bartosh and Zhaohui Wang and Bhooma Srinivasan and Anne Marie Brun-Zinkernagel and Rouel S. Roque},
  journal={In Vitro Cellular & Developmental Biology - Animal},
  year={2007},
  volume={43},
  pages={361-370}
}
A photoreceptor cell line, designated 661W, was tested for its response to growth factors secreted by retinal pigment epithelial cells including basic fibroblast growth factor, epidermal growth factor, and nerve growth factor. Early passaged 661W cells expressed high levels of retinal progenitor markers such as nestin and Pax6, but not opsin or glial fibrillary acidic protein. 661W cells grown in FGF-2 or EGF exhibited a multiple-process morphology with small phase-bright nuclei similar to… CONTINUE READING
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