RPB7, one of two dissociable subunits of yeast RNA polymerase II, is essential for cell viability.

@article{McKune1993RPB7OO,
  title={RPB7, one of two dissociable subunits of yeast RNA polymerase II, is essential for cell viability.},
  author={Keith McKune and Kathryn L Richards and Andrew M Edwards and Richard A. Young and Nancy A. Woychik},
  journal={Yeast},
  year={1993},
  volume={9 3},
  pages={295-9}
}
The Saccharomyces cerevisiae RNA polymerase II subunit gene RPB7 was isolated and sequenced. RPB7 is a single copy gene whose sequence predicts a 19,000 Dalton protein of 171 amino acids. RPB7 is known to dissociate from RNA polymerase II as an RPB4/RPB7 subcomplex in vitro. RPB7 also appears to interact with RNA polymerase II in a manner dependent upon RPB4, since RNA polymerase II purified from cells lacking RPB4 also lacks RPB7. Previous results have demonstrated that deletion of the RPB4… CONTINUE READING

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