RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA

Abstract

Immune recognition of cytosolic DNA represents a central antiviral defence mechanism. Within the host, short single-stranded DNA (ssDNA) continuously arises during the repair of DNA damage induced by endogenous and environmental genotoxic stress. Here we show that short ssDNA traverses the nuclear membrane, but is drawn into the nucleus by binding to the… (More)
DOI: 10.1038/ncomms11752

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