RP58 regulates the multipolar-bipolar transition of newborn neurons in the developing cerebral cortex.

@article{OhtakaMaruyama2013RP58RT,
  title={RP58 regulates the multipolar-bipolar transition of newborn neurons in the developing cerebral cortex.},
  author={Chiaki Ohtaka-Maruyama and Shinobu Hirai and Akiko Miwa and Julian Ik-Tsen Heng and Hiroshi Shitara and Rie Ishii and Choji Taya and Hitoshi Kawano and Masataka Kasai and Kazunori Nakajima and Haruo Okado},
  journal={Cell reports},
  year={2013},
  volume={3 2},
  pages={458-71}
}
Accumulating evidence suggests that many brain diseases are associated with defects in neuronal migration, suggesting that this step of neurogenesis is critical for brain organization. However, the molecular mechanisms underlying neuronal migration remain largely unknown. Here, we identified the zinc-finger transcriptional repressor RP58 as a key regulator of neuronal migration via multipolar-to-bipolar transition. RP58(-/-) neurons exhibited severe defects in the formation of leading processes… CONTINUE READING
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