RP105 Engages Phosphatidylinositol 3-Kinase p110δ To Facilitate the Trafficking and Secretion of Cytokines in Macrophages during Mycobacterial Infection.

@article{Yu2015RP105EP,
  title={RP105 Engages Phosphatidylinositol 3-Kinase p110δ To Facilitate the Trafficking and Secretion of Cytokines in Macrophages during Mycobacterial Infection.},
  author={Chien-Hsiung Alan Yu and Massimo Micaroni and Andreas Puyskens and Thomas E. Schultz and Jeremy Changyu Yeo and Amanda C. Stanley and Megan Lucas and Jade N Kurihara and Karen M Dobos and Jennifer L Stow and Antje Blumenthal},
  journal={Journal of immunology},
  year={2015},
  volume={195 8},
  pages={
          3890-900
        }
}
Cytokines are key regulators of adequate immune responses to infection with Mycobacterium tuberculosis. We demonstrate that the p110δ catalytic subunit of PI3K acts as a downstream effector of the TLR family member RP105 (CD180) in promoting mycobacteria-induced cytokine production by macrophages. Our data show that the significantly reduced release of TNF and IL-6 by RP105(-/-) macrophages during mycobacterial infection was not accompanied by diminished mRNA or protein expression. Mycobacteria… CONTINUE READING

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