RP-LC x RP-LC analysis of a tryptic digest using a combination of totally porous and partially porous stationary phases.

@article{Mondello2010RPLCXR,
  title={RP-LC x RP-LC analysis of a tryptic digest using a combination of totally porous and partially porous stationary phases.},
  author={Luigi Mondello and Paola Di Donato and F Cacciola and Chiara Fanali and Paola Dugo},
  journal={Journal of separation science},
  year={2010},
  volume={33 10},
  pages={1454-61}
}
Different chromatographic separation modes have been combined, in off-line and on-line approaches, attempting to achieve enhanced separation power for the analysis of complex proteome samples. Among these, the use of RP-LC x RP-LC brings in the added advantages of high peak capacity in both dimensions, capability of full automation, and the likelihood of… CONTINUE READING