RP-LC Resolution of (R,S)-Atenolol via Diastereomerization with Marfey’s Reagent and Its Structural Variants Under Conventional and Microwave Heating

@article{Bhushan2008RPLCRO,
  title={RP-LC Resolution of (R,S)-Atenolol via Diastereomerization with Marfey’s Reagent and Its Structural Variants Under Conventional and Microwave Heating},
  author={R. Bhushan and Shivani Tanwar},
  journal={Chromatographia},
  year={2008},
  volume={68},
  pages={849-853}
}
  • R. Bhushan, Shivani Tanwar
  • Published 2008
  • Chemistry
  • Chromatographia
    • Abstract(R,S)-Atenolol was derivatized with Marfey’s reagent, (MR; 1-fluoro-2,4-dinitrophenyl-5-l-alanine amide or FDNP-l-Ala-NH2) and its four structural variants (FDNP-l-Phe-NH2, FDNP-l-Val-NH2, FDNP-l-Leu-NH2 and FDNP-l-Pro-NH2). MR reacts quantitatively with 1° and 2° amino groups and atenolol has a secondary amino group. The derivatization reactions were carried out under conventional and microwave heating and compared. The resulting diastereomers were separated on RP-TLC and on a C18… CONTINUE READING
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    Highly Influential Citations
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    Background Citations
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