RP-HPLC enantioseparation of β-adrenolytics using micellar mobile phase without organic solvents.

@article{Alwera2017RPHPLCEO,
  title={RP-HPLC enantioseparation of β-adrenolytics using micellar mobile phase without organic solvents.},
  author={Shiv Alwera and R. Bhushan},
  journal={Biomedical chromatography : BMC},
  year={2017},
  volume={31 11}
}
  • Shiv Alwera, R. Bhushan
  • Published 2017
  • Chemistry, Medicine
  • Biomedical chromatography : BMC
  • Enantioseparation of a few commonly administered racemic β-adrenolytics (namely, carvedilol, betaxolol, salbutamol and bisoprolol) has been achieved using a water micellar mobile phase containing surfactants (sodium dodecyl sulphate and Brij-35) without organic solvents as a new approach in RP-HPLC. Two chiral derivatizing reagents based on enantiomerically pure (S)-(-)-levofloxacin were synthesized using N-hydroxysuccinimide and N-hydroxybenzotriazole as the activation auxiliaries… CONTINUE READING
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