• Chemistry
  • Published 2012

RP-HPLC METHOD FOR THE QUANTIFICATION OF VISMODEGIB IN FORMULATIONS

@inproceedings{Lakshmi2012RPHPLCMF,
  title={RP-HPLC METHOD FOR THE QUANTIFICATION OF VISMODEGIB IN FORMULATIONS},
  author={Bhagya Lakshmi and T. Veera Reddy},
  year={2012}
}
A simple, precise and accurate RP-HPLC method was developed and validated for rapid assay of Vismodegib in tablet dosage form. Isocratic elution at a flow rate of 1 mL/min was employed on a symmetry Chromosil C18 (250 mmx4.6 mm I.D., 5µm in particle size) at ambient temperature. The mobile phase consisted of Methanol: water: Acetonitrile 55:25:20 by volume. The UV detection wavelength was 236 nm and 20µl sample was injected. The retention time for Vismodegib was 8.29mins. The percentage RSD for… CONTINUE READING