RP-HPLC-DAD method for determination of olmesartan medoxomil in bulk and tablets exposed to forced conditions.

@article{Sharma2010RPHPLCDADMF,
  title={RP-HPLC-DAD method for determination of olmesartan medoxomil in bulk and tablets exposed to forced conditions.},
  author={Ritesh N. Sharma and Shyam Sunder Pancholi},
  journal={Acta pharmaceutica},
  year={2010},
  volume={60 1},
  pages={
          13-24
        }
}
A simple, sensitive and precise RP-HPLC-DAD method was developed and validated for the determination of olmesartan medoxomil (AT-II receptor blocker) in the presence of its degradation products. Olmesartan medoxomil and all the degradation products were resolved on a C(18) column with the mobile phase composed of methanol, acetonitrile and water (60:15:25, V/V/V, pH 3.5 by orthophosphoric acid) at 260 nm using a photodiode array detector. The method was linear over the concentration range of 1… CONTINUE READING

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