ROS1, a Repressor of Transcriptional Gene Silencing in Arabidopsis, Encodes a DNA Glycosylase/Lyase

@article{Gong2002ROS1AR,
  title={ROS1, a Repressor of Transcriptional Gene Silencing in Arabidopsis, Encodes a DNA Glycosylase/Lyase},
  author={Zhizhong Gong and Teresa Morales-Ruiz and Rafael R Ariza and Teresa Rold{\'a}n-Arjona and Lisa David and Jian-Kang Zhu},
  journal={Cell},
  year={2002},
  volume={111},
  pages={803-814}
}
Mutations in the Arabidopsis ROS1 locus cause transcriptional silencing of a transgene and a homologous endogenous gene. In the ros1 mutants, the promoter of the silenced loci is hypermethylated, which may be triggered by small RNAs produced from the transgene repeats. The transcriptional silencing in ros1 mutants can be released by the ddm1 mutation or the application of the DNA methylation inhibitor 5-aza-2'-deoxycytidine. ROS1 encodes an endonuclease III domain nuclear protein with… CONTINUE READING
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