ROS signaling by NADPH oxidase 5 modulates the proliferation and survival of prostate carcinoma cells

@inproceedings{Hoell2016ROSSB,
  title={ROS signaling by NADPH oxidase 5 modulates the proliferation and survival of prostate carcinoma cells},
  author={Monika Hoell and Rafal Koziel and Georg Sch{\"a}fer and Haymo Pircher and Alexander Pauck and Martin Hermann and Helmut Klocker and Pidder Jansen‐D{\"u}rr and Natalie Sampson},
  booktitle={Molecular carcinogenesis},
  year={2016}
}
Prostate cancer (PCa) is the most commonly diagnosed cancer and second leading cause of male cancer death in Western nations. Thus, new treatment modalities are urgently needed. Elevated production of reactive oxygen species (ROS) by NADPH oxidase (Nox) enzymes is implicated in tumorigenesis of the prostate and other tissues. However, the identity of the Nox enzyme(s) involved in prostate carcinogenesis remains largely unknown. Analysis of radical prostatectomy tissue samples and benign and… CONTINUE READING

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