ROS play a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor-associated macrophages

@inproceedings{Zhang2013ROSPA,
  title={ROS play a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor-associated macrophages},
  author={Yan Zhang and Swati Choksi and Kun Chen and Yelena L Pobezinskaya and Ilona R Linnoila and Zheng-gang Liu},
  booktitle={Cell Research},
  year={2013}
}
Differentiation to different types of macrophages determines their distinct functions. Tumor-associated macrophages (TAMs) promote tumorigenesis owing to their proangiogenic and immune-suppressive functions similar to those of alternatively activated (M2) macrophages. We report that reactive oxygen species (ROS) production is critical for macrophage differentiation and that inhibition of superoxide (O2−) production specifically blocks the differentiation of M2 macrophages. We found that when… CONTINUE READING
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