ROS-mediated iron overload injures the hematopoiesis of bone marrow by damaging hematopoietic stem/progenitor cells in mice

@inproceedings{Chai2015ROSmediatedIO,
  title={ROS-mediated iron overload injures the hematopoiesis of bone marrow by damaging hematopoietic stem/progenitor cells in mice},
  author={Xiao Chai and Deguan Li and Xiaoli Cao and Yuchen Zhang and Juan Mu and Wenyi Lu and Xia Xiao and Chengcheng Li and Juanxia Meng and Jie Chen and Qing Li and Ji Shi Wang and Aimin Meng and Mingfeng Zhao},
  booktitle={Scientific reports},
  year={2015}
}
Iron overload, caused by hereditary hemochromatosis or repeated blood transfusions in some diseases, such as beta thalassemia, bone marrow failure and myelodysplastic syndrome, can significantly induce injured bone marrow (BM) function as well as parenchyma organ dysfunctions. However, the effect of iron overload and its mechanism remain elusive. In this study, we investigated the effects of iron overload on the hematopoietic stem and progenitor cells (HSPCs) from a mouse model. Our results… CONTINUE READING

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The authors declare no competing financial interests

  • Okabe, 93 H.etal.Thebonemarrowhematopoieticmicroenvironmenti, +17 authors interpretation. J.W. helped perform the analysis with constructive interests
  • How to cite this article: Chai, X. et al. ROS…
  • 2015

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