ROS-mediated ERK activation in delayed protection from anoxic preconditioning in neonatal rat cardiomyocytes.

@article{Gong2004ROSmediatedEA,
  title={ROS-mediated ERK activation in delayed protection from anoxic preconditioning in neonatal rat cardiomyocytes.},
  author={Kai-zheng Gong and Zhen-gang Zhang and Ai-hua Li and Yi-feng Huang and Ping Bu and Feng Dong and Jian Liu},
  journal={Chinese medical journal},
  year={2004},
  volume={117 3},
  pages={395-400}
}
BACKGROUND The activation of extracellular signal-regulated kinase1/2 (ERK1/2) has been shown to be important signaling pathway in the ischemic preconditioning (IPC) response. Recently, some studies suggest a key role for the mitochondrial ATP-sensitive potassium channel (mKATP) as both a trigger and an end effector of acute and delayed protection of IPC. Hence, this study was undertaken to elucidate the relationship between mKATP and ERK1/2 in the delayed protection mechanism of anoxic… CONTINUE READING

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