ROS-dependent activation of autophagy is a critical mechanism for the induction of anti-glioma effect of sanguinarine.

@article{Pallichankandy2015ROSdependentAO,
  title={ROS-dependent activation of autophagy is a critical mechanism for the induction of anti-glioma effect of sanguinarine.},
  author={Siraj Pallichankandy and Anees Rahman and Faisal T Thayyullathil and Sehamuddin Galadari},
  journal={Free radical biology & medicine},
  year={2015},
  volume={89},
  pages={708-20}
}
Malignant gliomas are notoriously resistant to therapies that induce apoptosis, but are less resistant to therapies that induce autophagy. Therefore, drugs targeting autophagy are promising candidates in the treatment of malignant gliomas. In this study, we investigated the anti-glioma potential of sanguinarine (SNG) in vitro, and further examined the molecular mechanisms of SNG-induced cell death. In human malignant glioma cells SNG activated autophagic cell death pathway characterized by… CONTINUE READING
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