ROS as a tumour suppressor?

@article{Ramsey2006ROSAA,
  title={ROS as a tumour suppressor?},
  author={M. R. Ramsey and N. Sharpless},
  journal={Nature Cell Biology},
  year={2006},
  volume={8},
  pages={1213-1215}
}
  • M. R. Ramsey, N. Sharpless
  • Published 2006
  • Biology, Medicine
  • Nature Cell Biology
  • Senescence is an important mechanism for suppressing mammalian tumours and it may also contribute to aging. A new study suggests that changes in the metabolism of oxygen radicals are important for establishing senescence and blocking cytokinesis to ensure senescent cells never divide again. 
    177 Citations

    Figures and Topics from this paper.

    Explore Further: Topics Discussed in This Paper

    Telomeres, oxidative stress and inflammatory factors: partners in cellular senescence?
    • 117
    Cellular senescence: unravelling complexity
    • 40
    • PDF
    Cellular senescence: Its role in tumor suppression and aging
    • 93
    Mitochondria: Are they causal players in cellular senescence?
    • 86
    p53: new roles in metabolism.
    • 299
    Feedback between p21 and reactive oxygen production is necessary for cell senescence
    • 553
    • PDF
    Redox-based escape mechanism from death: the cancer lesson.
    • 80
    Cancer cell metabolism.
    • 124
    • PDF
    Cancer cell killing via ROS: To increase or decrease, that is the question
    • 494

    References

    SHOWING 1-10 OF 15 REFERENCES
    Senescence comes of age
    • 134
    Oxidant signals and oxidative stress.
    • T. Finkel
    • Biology, Medicine
    • Current opinion in cell biology
    • 2003
    • 1,255
    BRAFE600-associated senescence-like cell cycle arrest of human naevi
    • 1,875
    • PDF
    Reversal of human cellular senescence: roles of the p53 and p16 pathways
    • 1,028
    Cellular senescence in naevi and immortalisation in melanoma: a role for p16?
    • 348
    • PDF
    p16INK4a can initiate an autonomous senescence program
    • 145
    • PDF