ROS and RNS induced apoptosis through p53 and iNOS mediated pathway by a dibasic hydroxamic acid molecule in leukemia cells.

@article{Banerjee2014ROSAR,
  title={ROS and RNS induced apoptosis through p53 and iNOS mediated pathway by a dibasic hydroxamic acid molecule in leukemia cells.},
  author={Kaushik Banerjee and Avishek Ganguly and Paramita Chakraborty and Avijit Sarkar and Suryabhan Singh and Moitrayee Chatterjee and Subrato Bhattacharya and Soumitra Kumar Choudhuri},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year={2014},
  volume={52},
  pages={146-64}
}
Anticancer drugs induce apoptosis to cancer cells and also exhibit undesired toxicity to normal cells. Therefore development of novel agents triggering apoptosis and have low toxicity towards normal cells is most important. Hydroxamic acids suppress tumour cell growth through apoptosis but the underlying mechanism is poorly understood. Herein, we describe the apoptotic potential of a dibasic hydroxamic acid derivative, viz., oxayl bis (N-phenyl) hydroxamic acid (OBPHA), which induces apoptosis… CONTINUE READING