ROS and NO trigger early preconditioning: relationship to mitochondrial KATP channel.

@article{Lebuffe2003ROSAN,
  title={ROS and NO trigger early preconditioning: relationship to mitochondrial KATP channel.},
  author={Gilles Lebuffe and Paul T Schumacker and Z Shao and Travis Anderson and Hirotoro Iwase and Terry L Vanden Hoek},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2003},
  volume={284 1},
  pages={H299-308}
}
Reactive oxygen species (ROS) and nitric oxide (NO) are implicated in induction of ischemic preconditioning. However, the relationship between these oxidant signals and opening of the mitochondrial ATP-dependent potassium (K(ATP)) channel during early preconditioning is not fully understood. We observed preconditioning protection by hypoxia, exogenous H(2)O(2), or PKC activator PMA in cardiomyocytes subjected to 1-h ischemia and 3-h reperfusion. Protection was abolished by K(ATP) channel… CONTINUE READING

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