RORC2 is involved in T cell polarization through interaction with the FOXP3 promoter.

@article{Burgler2010RORC2II,
  title={RORC2 is involved in T cell polarization through interaction with the FOXP3 promoter.},
  author={Simone Burgler and Pierre-Yves Mantel and Claudio Bassin and Nadia Ouaked and Cezmi A Akdis and Carsten Schmidt-Weber},
  journal={Journal of immunology},
  year={2010},
  volume={184 11},
  pages={
          6161-9
        }
}
The process of Th cell differentiation toward polarized effector T cells tailors specific immunity against invading pathogens while allowing tolerance against commensal microorganisms, harmless allergens, or autologous Ags. Identification of the mechanisms underlying this polarization process is therefore central to understand how the immune system confers immunity and tolerance. The present study demonstrates that retinoic acid receptor-related orphan receptor C2 (RORC2), a key transcription… CONTINUE READING

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