ROR1C Regulates Differentiation of Myeloid-Derived Suppressor Cells.

Abstract

Myeloid-derived suppressor cells (MDSCs) play a major role in cancer. MDSC expansion is closely associated with tumor progression, but molecular mechanisms of this expansion remain poorly understood. In this issue of Cancer Cell, Strauss and colleagues describe the roles of the nuclear receptor ROR1C in the regulation of MDSC differentiation and expansion. 
DOI: 10.1016/j.ccell.2015.07.007

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