RORγt, but not T-bet, overexpression exacerbates an autoimmune model for multiple sclerosis.

Abstract

Th17 cells play an important role in multiple sclerosis (MS) and its autoimmune model, experimental autoimmune encephalomyelitis (EAE). However, studies have not addressed how enhanced Th17 immune responses can affect demyelinating diseases. We induced EAE with MOG in RORγt transgenic C57BL/6 mice that overexpress a Th17 inducing transcription factor. RORγt… (More)
DOI: 10.1016/j.jneuroim.2014.09.006

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