RORα Coordinates Reciprocal Signaling in Cerebellar Development through Sonic hedgehog and Calcium-Dependent Pathways

@article{Gold2003RORCR,
  title={RORα Coordinates Reciprocal Signaling in Cerebellar Development through Sonic hedgehog and Calcium-Dependent Pathways},
  author={David A. Gold and Sung Hee Baek and Nicholas J. Schork and David W. Rose and Delaine D Larsen and Benjamin D. Sachs and Michael G. Rosenfeld and Bruce A Hamilton},
  journal={Neuron},
  year={2003},
  volume={40},
  pages={1119-1131}
}
The cerebellum provides an excellent system for understanding how afferent and target neurons coordinate sequential intercellular signals and cell-autonomous genetic programs in development. Mutations in the orphan nuclear receptor RORalpha block Purkinje cell differentiation with a secondary loss of afferent granule cells. We show that early transcriptional targets of RORalpha include both mitogenic signals for afferent progenitors and signal transduction genes required to process their… CONTINUE READING
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