• Corpus ID: 53500450

ROLE OF WITHANIA SOMNIFERA IN PREVENTION AND TREATMENT OF CANCER: AN OVERVIEW

@article{Singh2011ROLEOW,
  title={ROLE OF WITHANIA SOMNIFERA IN PREVENTION AND TREATMENT OF CANCER: AN OVERVIEW},
  author={Narendra Kumar Singh and Pankaj Verma and B. R. Pandey and Marilena Gilca},
  journal={International Journal of Pharmaceutical Sciences and Drug Research},
  year={2011},
  pages={274-279}
}
  • N. Singh, P. Verma, +1 author M. Gilca
  • Published 1 October 2011
  • Medicine
  • International Journal of Pharmaceutical Sciences and Drug Research
Cancer is hyperproliferative disorder that involves transformation, dysregulation of apoptosis, proliferation, invasion, angiogenesis and metastasis. Millions of people die every year with different types of cancer such as lung cancer and mesothelioma from inhaling asbestos fibers and tobacco smoke, or leukemia from exposure to benzene at their workplaces. In the last century, great advances were made in modern medical system in cure and prevent of this disease. However, success rates are very… 
Withania Somnifera: A New Approach To Cancer
TLDR
A popular ayurvedic herb Withania Somnifera (WS) also known as Indian Winter Cherry and Indian Ginseng is used as a traditional medicine for various cancers and is effective in prevention and treatment of different kinds of cancer.
Withania somnifera targets interleukin-8 and cyclooxygenase-2 in human prostate cancer progression
TLDR
The results indicate that inherent metastatic and selective inhibitory potential of W. somnifera may be a good therapeutic agent in addition to the existing drugs for PC, and a significant decrease in the cell viability was observed with a half-maximal inhibitory concentration.
Medicinal Plants and Other Living Organisms with Antitumor Potential against Lung Cancer
TLDR
It is shown that natural products from plants continue to be a rich source of herbal medicines or biologically active compounds against cancer and Mechanisms of action, combination with chemotherapeutic drugs, and new technologies to increase activity and reduce the toxicity of the treatment are discussed.
ASHWAGANDHA ( WITHANIA SOMNIFERA ) AS ANTICANCER HERB : AN OVERVIEW
Withania somnifera commonly called as Ashwagandha is a widely used medicinal herb in Ayurveda. It is considered to be a Rasayana herb, an adaptogen, and is commonly referred to as ‘Indian ginseng’.
ORGANIC POLY HERBAL INTERVENTION IN TREATMENT OF ORAL CANCER: A CLINICAL STUDY
TLDR
This herbal formulation showed beneficial effect in patients of oral cancer when treatment was continued over a period of about one year thereby suggesting its long term use as complimentary or alternative therapy in prevention and treatment of the oral cancer.
Effect of Withania somnifera root extract on spontaneous estrogen receptor-negative mammary cancer in MMTV/Neu mice.
TLDR
The cancer-preventive activity of an extract of Withania somnifera roots was examined in female transgenic mice that received a diet containing the extract and results indicate that the root extract reduced the number of mammary carcinomas that developed and reduced the rate of cell division in the carcinomas.
Chemistry and pharmacology of withania somnifera: An update
Withania somnifera (Ashwagandha) is an important Rasayana herb and widely considered as Indian ginseng in Ayurveda. In traditional system of Indian medicine, it is used as tonic to rejuvenate the
Effect of an extract of Withania somnifera root on estrogen receptor-positive mammary carcinomas.
TLDR
The chemopreventive activity of an extract of Withania somnifera roots was examined in female Sprague-Dawley rats that received the mammary carcinogen methylnitrosourea, and results indicate that the root extract significantly reduced the rate of cell division in the mammaries.
The effects of Rhamnus frangula miller leaf extract on breast cancer cells viability in cell culture
TLDR
The findings indicated that low dose of the Rhamnus frangula leaf extract has no significant cytotoxic effect on MCF-7 cells, however, high doses of extract of have cytot toxic effects on MCf-7 Cells.
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References

SHOWING 1-10 OF 56 REFERENCES
Roots of Withania somnifera Inhibit Forestomach and Skin Carcinogenesis in Mice
TLDR
The findings suggest that W.somnifera root has chemopreventive efficacy against forestomach and skin carcinogenesis and warrants the identification and isolation of active compounds responsible for its anticancer effects, which may provide the lead for the development of antitumor agents.
From traditional Ayurvedic medicine to modern medicine: identification of therapeutic targets for suppression of inflammation and cancer
TLDR
The focus of this review is to elucidate the Ayurvedic concept of cancer, including its classification, causes, pathogenesis and prevention; surgical removal of tumours; herbal remedies; dietary modifications; and spiritual treatments.
Immunomodulatory Effects of Withania Somnifera on Azoxymethane Induced Experimental Colon Cancer in Mice
TLDR
The immunomodulatory effects of W. somnifera could be useful in the treatment of colon cancer, as suggested by results suggested in experimental azoxymethane induced colon cancer in mice.
In Vitro Anticancer Activity of the Root, Stem and Leaves of Withania Somnifera against Various Human Cancer Cell Lines
TLDR
This investigation is the first report of the anticancer activity in various parts of Withania Somnifera cultivated in fly ash amended soil.
Notch-1 Inhibition by Withaferin-A: A Therapeutic Target against Colon Carcinogenesis
TLDR
Withaferin-A (WA) is a bioactive compound derived from Withania somnifera, which inhibits Notch-1 signaling and downregulates prosurvival pathways, such as Akt/NF-κB/Bcl-2, in three colon cancer cell lines.
Enhancement of antitumor effect of paclitaxel in combination with immunomodulatory Withania somnifera on benzo(a)pyrene induced experimental lung cancer.
TLDR
The immunomodulatory activity of W. somnifera (L.) Dunal extract, which is a known Immunomodulator in indigenous medicine, is concluded against benzo(a)pyrene induced lung cancer in male Swiss albino mice.
Withaferin A induces apoptosis in human melanoma cells through generation of reactive oxygen species and down-regulation of Bcl-2
TLDR
The results support the therapeutic potential of WFA against human melanoma, which requires early reactive oxygen species production and glutathione depletion and the inhibition of ROS increase by the antioxidant N-acetylcysteine resulting in complete suppression of mitochondrial and nuclear events.
Screening of indigenous Palestinian medicinal plants for potential anti-inflammatory and cytotoxic activity.
TLDR
Whereas Withania somnifera extract demonstrated the strongest NFkappaB-inhibitory activity, other extracts derived from Laurus nobilis, Psidium guajava and Foeniculum vulgare M. (Umbiliferrae) also revealed immunomodulatory NFKappaB activities, and are good candidates for further activity-monitored fractionation to identify active constituents.
Chemotherapeutic efficacy of paclitaxel in combination with Withania somnifera on benzo(a)pyrene‐induced experimental lung cancer
TLDR
The data suggest that paclitaxel, administered with W. somnifera, may extend its chemotherapeutic effect through modulating protein‐bound carbohydrate levels and marker enzymes, as they are indicators of cancer, by effectively treating benzo(a)pyrene‐induced lung cancer in mice.
Chemopreventive activity of Withania somnifera in experimentally induced fibrosarcoma tumours in Swiss albino mice.
TLDR
Oral treatment of animals with 400 mg/kg body weight of Withania somnifera extract significantly reduced the tumour incidence, tumour volume and enhanced the survival of the mice, compared with 20-methylcholanthrene injected mice, and Liver biochemical parameters revealed a significant modulation of reduced glutathione, lipid peroxides, glutathion-S-transferase, catalase and superoxide dismutase in extract treated mice.
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