ROLE OF PINEAL GLAND IN ÆTIOLOGY AND TREATMENT OF BREAST CANCER

@article{Cohen1978ROLEOP,
  title={ROLE OF PINEAL GLAND IN {\aE}TIOLOGY AND TREATMENT OF BREAST CANCER},
  author={Michael Cohen and Marc E. Lippman and Bruce A. Chabner},
  journal={The Lancet},
  year={1978},
  volume={312},
  pages={814-816}
}

The role of pineal gland in breast cancer development.

  • V. Anisimov
  • Biology, Medicine
    Critical reviews in oncology/hematology
  • 2003

Role of the pineal gland in the development of malignant melanoma

The Pineal Gland and Breast Cancer: Serum Levels of Melatonin in Patients with Mammary Tumors and Their Relation to Clinical Characteristics

Several studies have suggested that the pineal gland hormone melatonin may influence the growth of breast cancer. The importance of melatonin blood concentrations in the clinical history of human

Melatonin increases oestrogen receptor binding activity of human breast cancer cells

TLDR
In vitro incubation of MCF-7 human breast cancer cells with melatonin in physiological conditions increased the cytoplasmic and nuclear ER activity of these cells within 40 min, giving no change in the equilibrium dissociation constant (Kd) of the receptor.

Melatonin and Mammary Pathological Growth

TLDR
The general conclusion is that experimental manipulations activating the pineal gland, or the administration of melatonin, enlarge the latency and reduce the incidence and growth rate of chemically induced mammary tumors, while pinealectomy usually has the opposite effects.

International Congress on Hormonal Steroids and Hormones and Cancer Melatonin and mammary cancer: a short review

TLDR
In vitro experiments have demonstrated that melatonin down-regulates the expression of ERα and inhibits the binding of the estradiol–ER complex to the estrogen response element (ERE) in the DNA, which reduces the incidence and growth rate of mammary tumors and reduces the metastasic capacity of these cells.

Endocrinology of breast cancer.

Analysis of Melatonin in Patients with Cancer of the Reproductive System

TLDR
Findings relating to the concentrations of circulating melatonin as well as of the urinary excretion of 6-sulfatoxymelatonin (aMT6s, main peripheral metabolite of melatonin) in patients with different types of cancer of the reproductive system are summarized to achieve a better understanding of the modulation of signaling processes within the neuroimmunoendocrine network due to neoplasia.

Possible association between breast cancer and malignant melanoma.

TLDR
Depressed pineal gland secretion of melatonin might hypothetically contribute to the development of both breast cancer and malignant melanoma.

Melatonin: perspectives in laboratory medicine and clinical research.

TLDR
The demonstration of markedly elevated melatonin secretion in patients with spina bifida occulta might suggest that assay of melatonin in amniotic fluid could be useful as an experimental adjunct in the prenatal diagnosis of this condition.
...

References

SHOWING 1-10 OF 15 REFERENCES

Evidence for a cytoplasmic melatonin receptor

TLDR
Evidence is reported for the presence of a specific melatonin receptor in the supernatant fraction of several organs in hamster and rat tissues and human ovaries.

Gonadal steroids as modulators of the function of the pineal gland.

Influence of pineal gland on the growth and spread of melanoma in the hamster.

TLDR
The pinealectomized group of hamsters had significantly larger primary tumors and more extensive metastases than the control or sham-operated animals at every phase of the study, possible indications of a relationship between the pineal gland and growth and spread of pigmented melanomata in hamsters.

Elevated serum levels of estrogen and prolactin in daughters of patients with breast cancer.

Demographic risk factors in sisters and daughters of 150 patients with breast cancer were compared to those of controls. Plasma hormone levels in 36 teen-age daughters of patients and 31 controls

The effect of melatonin on steroidogenesis by the human ovary in vitro.

TLDR
Observations suggest that melatonin may directly modulate steroidogenesis in the human ovary and no specific binding of radioactive melatonin of low specific activity could be detected in homogenates of a human corpus luteum.

Effect of Chlorpromazine and Other Drugs on the Disposition of Circulating Melatonin

TLDR
The pineal gland has the unique ability to synthesize methoxyindoles such as melatonin and methoxytryptophol, and it has been claimed that melatonin acts on the thyroid, gut, pituitary, skin and brain.

Effects of castration and testosterone administration on pineal and retinal hydroxyindole-O-methyl transferases of male rats.

TLDR
The effects of castration andtestosterone treatment on pineal and retinal hydroxyindole-O-methyl transferases (HIOMT) were investigated in male rats and activities decreased 24–7.

The pineal gland: a neurochemical transducer.

In this article, Axelrod applied signal transduction theory to his research on the metabolic function of serotonin, even describing the pineal gland as a "neurochemical transducer."

Comparison of seasonal influence on pregnancy duration in man and domestic animals

  • P. Cohen
  • Biology, Medicine
    International journal of biometeorology
  • 1970
TLDR
This comparison showed a similar trend occurring in the different species, indicating the existence of a general factor, participating in causing the variations, and the possibility that this factor is, in an indirect way, connected with daylight changes, is discussed.