The role of pineal gland in breast cancer development.
- Biology, MedicineCritical reviews in oncology/hematology
Role of the pineal gland in the development of malignant melanoma
- Medicine, BiologyNeurochemistry International
The Pineal Gland and Breast Cancer: Serum Levels of Melatonin in Patients with Mammary Tumors and Their Relation to Clinical Characteristics
- Medicine, BiologyThe International journal of biological markers
Several studies have suggested that the pineal gland hormone melatonin may influence the growth of breast cancer. The importance of melatonin blood concentrations in the clinical history of human…
Melatonin increases oestrogen receptor binding activity of human breast cancer cells
- Biology, MedicineNature
In vitro incubation of MCF-7 human breast cancer cells with melatonin in physiological conditions increased the cytoplasmic and nuclear ER activity of these cells within 40 min, giving no change in the equilibrium dissociation constant (Kd) of the receptor.
Melatonin and Mammary Pathological Growth
- Biology, MedicineFrontiers in Neuroendocrinology
The general conclusion is that experimental manipulations activating the pineal gland, or the administration of melatonin, enlarge the latency and reduce the incidence and growth rate of chemically induced mammary tumors, while pinealectomy usually has the opposite effects.
International Congress on Hormonal Steroids and Hormones and Cancer Melatonin and mammary cancer: a short review
- Biology, Medicine
In vitro experiments have demonstrated that melatonin down-regulates the expression of ERα and inhibits the binding of the estradiol–ER complex to the estrogen response element (ERE) in the DNA, which reduces the incidence and growth rate of mammary tumors and reduces the metastasic capacity of these cells.
Analysis of Melatonin in Patients with Cancer of the Reproductive System
- Medicine, Biology
Findings relating to the concentrations of circulating melatonin as well as of the urinary excretion of 6-sulfatoxymelatonin (aMT6s, main peripheral metabolite of melatonin) in patients with different types of cancer of the reproductive system are summarized to achieve a better understanding of the modulation of signaling processes within the neuroimmunoendocrine network due to neoplasia.
Possible association between breast cancer and malignant melanoma.
- Medicine, BiologyArchives of dermatology
Depressed pineal gland secretion of melatonin might hypothetically contribute to the development of both breast cancer and malignant melanoma.
Melatonin: perspectives in laboratory medicine and clinical research.
- Medicine, BiologyCritical reviews in clinical laboratory sciences
The demonstration of markedly elevated melatonin secretion in patients with spina bifida occulta might suggest that assay of melatonin in amniotic fluid could be useful as an experimental adjunct in the prenatal diagnosis of this condition.
SHOWING 1-10 OF 15 REFERENCES
Evidence for a cytoplasmic melatonin receptor
- Biology, MedicineNature
Evidence is reported for the presence of a specific melatonin receptor in the supernatant fraction of several organs in hamster and rat tissues and human ovaries.
Gonadal steroids as modulators of the function of the pineal gland.
- Biology, MedicineGeneral and comparative endocrinology
Influence of pineal gland on the growth and spread of melanoma in the hamster.
- BiologyCancer research
The pinealectomized group of hamsters had significantly larger primary tumors and more extensive metastases than the control or sham-operated animals at every phase of the study, possible indications of a relationship between the pineal gland and growth and spread of pigmented melanomata in hamsters.
Testicular responses to melatonin and serotonin implanted peripherally in immature rats
- Biology, Medicine
Elevated serum levels of estrogen and prolactin in daughters of patients with breast cancer.
- Medicine, BiologyThe New England journal of medicine
Demographic risk factors in sisters and daughters of 150 patients with breast cancer were compared to those of controls. Plasma hormone levels in 36 teen-age daughters of patients and 31 controls…
The effect of melatonin on steroidogenesis by the human ovary in vitro.
- BiologyThe Journal of clinical endocrinology and metabolism
Observations suggest that melatonin may directly modulate steroidogenesis in the human ovary and no specific binding of radioactive melatonin of low specific activity could be detected in homogenates of a human corpus luteum.
Effect of Chlorpromazine and Other Drugs on the Disposition of Circulating Melatonin
The pineal gland has the unique ability to synthesize methoxyindoles such as melatonin and methoxytryptophol, and it has been claimed that melatonin acts on the thyroid, gut, pituitary, skin and brain.
Effects of castration and testosterone administration on pineal and retinal hydroxyindole-O-methyl transferases of male rats.
- Biology, MedicineNeuroendocrinology
The effects of castration andtestosterone treatment on pineal and retinal hydroxyindole-O-methyl transferases (HIOMT) were investigated in male rats and activities decreased 24–7.
The pineal gland: a neurochemical transducer.
In this article, Axelrod applied signal transduction theory to his research on the metabolic function of serotonin, even describing the pineal gland as a "neurochemical transducer."
Comparison of seasonal influence on pregnancy duration in man and domestic animals
- Biology, MedicineInternational journal of biometeorology
This comparison showed a similar trend occurring in the different species, indicating the existence of a general factor, participating in causing the variations, and the possibility that this factor is, in an indirect way, connected with daylight changes, is discussed.