• Corpus ID: 52210634


  author={A. Venket Rao},
Lycopene is a naturally present carotenoid in tomatoes. Among the carotenoids, lycopene is a major component found in the serum. High levels of lycopene have also been found in the testes, adrenal glands, prostate. Several recent studies including cell culture, animal and epidemiological investigations have indicated the effect of dietary lycopene in reducing the risk of chronic diseases such as cancer and coronary heart disease. Although, the antioxidant properties of lycopene are thought to… 

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The potential role of lycopene for human health.

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  • 1997
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Lycopene: chemistry, biology, and implications for human health and disease.

This review will summarize the knowledge in lycopene bioavailability, tissue distribution, metabolism, excretion, and biological actions in experimental animals and humans as well as the associations between lycopenes consumption and human health.

Lutein, lycopene, and their oxidative metabolites in chemoprevention of cancer

A possible antioxidant mechanism of action for lutein and lycopene that leads to formation of the oxidation products of these promising chemopreventive agents is proposed.

Uptake of lycopene and its geometrical isomers is greater from heat-processed than from unprocessed tomato juice in humans.

The uptake of lycopene from processed and unprocessed tomato juice in humans and the increase in peak serum concentrations was dose-dependent but not linear with the dose, which led to a continual rise of Lycopene in human serum.

cis-trans lycopene isomers, carotenoids, and retinol in the human prostate.

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The hypothesis that lycopene may have direct effects within the prostate and contribute to the reduced prostate cancer risk associated with the reduction in the consumption of tomato-based foods is supported.

Hypocholesterolemic effect of lycopene and beta-carotene is related to suppression of cholesterol synthesis and augmentation of LDL receptor activity in macrophages.

It is concluded that dietary supplementation of carotenoids may act as moderate hypocholesterolemic agents, secondary to their inhibitory effect on macrophage 3-hydroxy-3-methyl glutaryl coenzyme A (HMGCoA) reductase, the rate limiting enzyme in cholesterol synthesis.

Lycopene is a more potent inhibitor of human cancer cell proliferation than either alpha-carotene or beta-carotene.

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