ROLE OF INTERLEUKIN‐6 IN THE PATHOGENESIS OF MULTIPLE MYELOMA

@article{Gad2000ROLEOI,
  title={ROLE OF INTERLEUKIN‐6 IN THE PATHOGENESIS OF MULTIPLE MYELOMA},
  author={Klara Gad{\'o} and Gyula Domj{\'a}n and Hargita Hegyesi and Andr{\'a}s Falus},
  journal={Cell Biology International},
  year={2000},
  volume={24}
}
Multiple myeloma (MM) is a currently incurable disease caused by the proliferation of malignant plasma cells. Although the pathogenesis of the disease still remains unclear, recent research in the biology of MM has produced new insights into the factors that control the growth and survival of myeloma cells. Among the growth factors, interleukin‐6 (IL‐6) has an essential role. Evidence suggests that IL‐6 is not only a growth factor, but also a survival factor in MM, inhibiting apoptosis in… 
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Mechanisms of sensitization to apoptosis in multiple myeloma.
TLDR
It is demonstrated that the mTOR-inhibitor rapamycin alone induced apoptosis in primary MM cells and inhibition of GSK3 counteracts growth inhibition induced by dexamethasone alone and in combinatorial treatments with inhibitors against PI 3-kinase, mitogen-activated protein kinase (MEK), mTOR and IGF-1R.
Targeting signalling pathways for the treatment of multiple myeloma
TLDR
Close collaboration between basic researchers and clinicians will be required to further improve the knowledge of MM pathophysiologically in order to translate advances from the bench to the bedside and improve patient outcome.
Tumor-associated macrophages in multiple myeloma: advances in biology and therapy
TLDR
An updated and comprehensive overview into the current knowledge on the roles of TAMs in MM, as well as the therapeutic targets that are being explored as macrophage-targeted immunotherapy, which may hold key to future therapeutics against MM are provided.
Immunological Prognostic Factors in Multiple Myeloma
TLDR
This review focuses on characterizing the components of the immune system that are of prognostic value in MM patients, in order to facilitate the development of new diagnostic and therapeutic directions.
Multiple Myeloma : an update on disease biology and therapy
TLDR
Recent developments in the molecular pathogenesis of myeloma are discussed and novel therapeutic approaches that target both the tumor cell as well as the stroma are discussed.
The role of IL-29 in immunity and cancer
The Effect of Telomerase Inhibition on the Expression of Inflammatory Cytokines Affecting the Pathogenesis of Multiple Myeloma Cell Line U266
TLDR
The effect of MST-312 (a derivative of green tea with telomerase inhibition activity) was investigated on the treated U266 cell line and the expression of inflammatory cytokines and the NF-κB signaling pathway.
Activation of sphingosine kinase mediates suppressive effect of interleukin‐6 on human multiple myeloma cell apoptosis
TLDR
Results delineate a key role for SPHK activation in IL‐6‐induced proliferation and survival of MM cells, and suggest that SPHK may be a potential new therapeutic target in MM.
Obesity and Multiple Myeloma
TLDR
Obesity is consistently associated with increased risk and drives mechanistic pathways important in its development and diagnosis and treatment of MM patients are considered in the context of obesity as a cause with potential impact on treatment and outcomes.
Extracellular S100A9 Protein in Bone Marrow Supports Multiple Myeloma Survival by Stimulating Angiogenesis and Cytokine Secretion
TLDR
The data suggest that extracellular S 100A9 promotes MM and that inhibition of S100A9 may have therapeutic benefit, and that ABR-238901 treatment in combination with bortezomib resulted in an increased reduction in tumor load compared with single treatments.
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