ROLE OF ENDOGENOUS IGFBP-3 IN MAMMARY EPITHELIAL CELL APOPTOSIS

@inproceedings{AgostiniDreyer2014ROLEOE,
  title={ROLE OF ENDOGENOUS IGFBP-3 IN MAMMARY EPITHELIAL CELL APOPTOSIS},
  author={Allyson M. Agostini-Dreyer},
  year={2014}
}
Mammary epithelial cell (MEC) number is an important determinant of milk production in lactating dairy cows. IGF-I increases IGF binding protein-3 (IGFBP-3) production in these cells, which plays a role in its ability to enhance proliferation. In the present study, we show that the apoptotic factor anisomycin (ANS) also increases IGFBP-3 mRNA and protein in a dose and concentration-dependent manner that mirrors activation of caspase-3 and -7, with significant increases in both IGFBP-3 protein… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 193 REFERENCES

Insulin-like growth factor binding protein-3 (IGFBP-3): Novel ligands mediate unexpected functions

  • RC Baxter
  • Journal of cell communication and signaling
  • 2013
Highly Influential
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